1.2020 Potent and selective PTP1B inhibition by a platinum(II) complex possible implications for a new antitumor strategy

Showing anti-proliferation activity against MCF7 cells better than cisplatin, a platinum(II) complex, [PtL(DMSO)Cl], was found to potently and selectively inhibit protein tyrosine phosphatase 1B (PTP1B), a putative target for anticancer agents, suggesting a new possible anticancer strategy based on platinum drugs